Chronic Diseases Prevention Review (Online ISSN: 2158-0820)

by Xiaotian Gao, Jiexin Zhao, Feng Gao, Jin Xie, Fei Liu, Luoyi Shi

Chronic Diseases Prevention Review 2021 5(18) 1-7; published online  19 September2021

Abstract: Stroke induces mood and cognitive impairments, about 30% of which are antidepressants-resistant. To investigate the evidence and related molecular mechanisms of fluoxetine on fluoxetine-resistant sedentary ischemic stroke rats. Wistar rats after middle cerebral artery occlusion/reperfusion were randomly divided into Sham, Sedentary, fluoxetine-effective (Flu-E), fluoxetine-resistant (Flu-R) groups. The behavioral tests (open field test for anxiety, and delayed non-matching to place task for spatial pattern separation) were performed before and after intervention. We investigated regional changes in neurogenesis by immunohistochemical staining for doublecortin (DCX) and brainderived neurotrophic factor (BDNF) in the dorsal dentate gyrus (dDG) and ventral DG (vDG). The depression behaviors with pattern separation deficit and impaired hippocampal neurogenesis in the dDG were found in the fluoxetine-resistant sedentary cerebral ischemic rats. Fluoxetine significantly increased the BDNF and DCX expression level in the both dDG and vDG in the fluoxetine-effective rats, while there was no significant difference in fluoxetine-resistant group. Traditional antidepressants for treating depressive disorders with cognitive deficits have limited efficacy. It is necessary to explore the region-specific effects of stress on neurogenesis and region-specific changes in cognitive and emotional behaviors along the septo-temporal axis of hippocampus.