Chronic Diseases Prevention Review (Online ISSN: 2158-0820)

by  Xiaoshu Guo, Lin Xu, Junwei Huang, Min Zhao

Chronic Diseases Prevention Review 2017 1(1) 1-6; published online 7 January 2017

Abstract: To study the difference of serum calcium (Ca²⁺) and magnesium (Mg²⁺) levels between preeclampsia (PE) pregnant women and normal pregnancy, and the effects on uterine artery blood flow resistance. This case-control study was conducted on 360 pregnant women (≥20 weeks gestation) received antenatal care at Affiliated Hospital of Qingdao University. The cases include 80 pregnant women with mild preeclampsia (MPE), 120 women with severe preeclampsia (SPE). The control group has 160 healthy and age matched pregnant women who were not received mineral during pregnancy. Demographic, anthropometric, clinical and obstetric data were gathered by an interview-based questionnaire. Venous blood samples were drawn for the measurement of serum Ca²⁺ and Mg²⁺ level. Doppler ultrasound was used to reflect the dynamic change of uterine artery. Pregnant women with SPE have significantly lower serum Ca²⁺ and Mg²⁺ levels than control group and pregnant women with MPE (OR=39.67, P<0.05). The uterine artery blood flow resistance in SPE is higher than others (P<0.05). This study shows that hypocalcemia and hypomagnesemia are the risk factors of SPE. Uterine artery blood flow resistance may be related to the decreased concentration of serum Ca²⁺ and Mg2+ levels.

by Dehui Zhu, Ze Wang, Chuanjian Yi, Xiqin Liu, Xiaojun Ji 

Chronic Diseases Prevention Review 2017 1(1) 7-9; published online 7 January 2017

Abstract: To observe the curative effect of the single point of continuing hands deep thumb pressure rubbing method to the stroke patient with lower limb flexor spasticity. After seeking for spastic muscle, the patient was treated with the method of a single point of continuing hands deep thumb pressure rubbing method. The treatment was 3~5 seconds with the single point of continuing hands deep thumb pressure rubbing method, and the patient had a rest for 6~10 seconds after the treatment, twice a day, 35 minutes each time. The spastic muscle of the patient had a great improvement. And the patient could self-care after treatment. The single point of continuing hands deep thumb pressure rubbing method has obvious effect on the lower limb flexor spasticity of stroke patients.

by  Zuzhou Huang, Ru Zhang, Jiang Li, Zhongcui Jing, Xuewen Jia, Chang Liu, Chunmei Wu, Shiguo Liu

Chronic Diseases Prevention Review 2017 1(1) 10-15; published online 7 January 2017

Abstract: Previous studies have suggested a critical role for interleukin IL-17F in innate and adaptive immunity in vivo and its abnormal expression was found to play a bridging role in several neurological disorders. In this study, we investigated the association between functional polymorphisms in IL-17F and Tourette’s syndrome (TS) in a Chinese Han population. We recruited 407 TS nuclear family trios (325 male cases and 82 female cases each with their parents) and 417 controls (321 male and 96 female), and performed TaqMan allelic discrimination real-time PCR to genotype two polymorphisms in IL-17F, rs1889570 and rs763780. The transmission disequilibrium test (TDT) and haplotype relative risk (HRR) were used to estimate genetic susceptibility. In addition, we designed a classic case–control study to identify differences in the genetic distributions of these polymorphisms. No transmission disequilibrium was found between the IL-17F tag polymorphisms rs1889570 and rs763780 and TS (rs1889570: TDT=1.35, P=0.266, HRR=1.327, χ²=3.812, P=0.051, 95%CI=0.999-1.763, haplotype-based HRR (HHRR)=1.127, χ²=1.371, P=0.242, 95%CI=0.923-1.376; rs763780: TDT=3.10, P=0.092, HRR=0.74, χ²=3.00, P=0.083, 95%CI=0.526-1.041, HHRR=0.75, χ²=3.146, P=0.076, 95%CI=0.546-1.031). The allelic frequencies and genotypic distributions were compared by Pearson’s chi-square test, which also indicated there was no remarkable difference between the TS patients and the controls. Our research indicated that the genetic variants of rs763780 and rs1889570 in IL-17F may not play a crucial role in the pathogenesis of TS in a Chinese Han population. However, these findings should be confirmed in other ethnic populations.

by  Ming Kong, Li Song, Hui Huang, Xue Liu, Chunhua Wang, Xinyuan Kong

Chronic Diseases Prevention Review 2017 1(1) 16-19; published online 22 January 2017

Abstract: Dexmedetomidine is a new type of high selective α2-AR agonist with the effect of analgesia and sedation. The majority of the posterior spinal surgery should to be carried out in the prone position. Changes in body position can also lead to change in lung compliance. This kind of operation of dexmedetomidine intravenous injection on respiratory mechanics effect is not clear. This research is to observe the effect of dexmedetomidine intravenous injection with effect and cycle of lung in patients with posterior spinal surgery under general anesthesia. The study paper adopts the placebo-controlled, randomized, double-blind method. Consecutive patients were randomly divided into test group (group D) and blank group (group C). Two groups of patients were treated with intravenous anesthesia. Group D are treated with anesthesia inducting vein pump injection dexmedetomidine 0.5μg/kg•min in 10minutes, maintaining the 0.05μg/kg•h later. The group C pumps into the same amount of 0.9%physiological saline. We had recorded airway pressure (Ppeak) dynamic lung compliance (Cdyn) static lung compliance (Cstat), heart rate (HR) end-tidal pressure of carbon dioxide (PETCO₂) at the time of 5min before the aesthesia (T0), at the time of 5min after the anesthesia (T1), at the time of 1h after the aesthesia (T2), at the time of 2h after the anesthesia (T3). The data of two groups at different time points were statistically significant in Ppeak Cdyn HR PETCO2 Cstat (P<0.05). Dexmedetomidine can significantly relieve the decrease of Ppeak, Cdyn, Cstat caused by mechanical control ventilation after the general anesthesia of the prone position surgery patients, and it can make the patients’ blood pressure, heart rate and hemodynamic more stable.