Chronic Diseases Prevention Review (Online ISSN: 2158-0820)
Current Issue
Vol.3 No.10
Article: Protective effect of hydrogen sulfide on articular cartilage
by Xianan Li, Shaoqi Tian, Yuanhe Wang, Jiangjun Liu, Tao Ding, Guoqing Chu, Kang Sun
Chronic Diseases Prevention Review 2019 3(10) 1-6; published online 18 April 2019
Abstract:
To investigate the effect of H2S on articular
cartilage degeneration in rabbit knee osteoarthritis model
and to explore the protective effect of H2S on
osteoarthritis. Thirty-two New Zealand white rabbits were
randomly divided into four groups: blank control group, OA
model group, H2S intervention group and H2S
inhibition group, with 8 rabbits in each group. Group A was
not treated. Group B, C and D were injected with saline,
NaHS diluent and H2S inhibitor 1 ml each into the
knee joint cavity once a week for 6 weeks to establish OA
model. Animals were sacrificed 7 weeks after operation.
Articular cartilage was taken for HE staining, and scored
according to Mankin's method. The expression of collagen
type II in cartilage was detected by immunohistochemistry,
and the expression of MMP-1, MMP-3 and MMP-13 in cartilage
was detected by Real-time PCR. Mankin's score showed that
the scores of group B, C and D were higher than those of
group A (P<0.05). The scores of group C were lower than
those of group B, and the scores of group D were higher than
those of group B (P<0.05). Type II collagen staining showed
that compared with group A, the positive staining of type II
collagen in group B was significantly lower and unevenly
distributed; the positive staining of type II collagen in
group C was higher than that in group B; the positive
staining of type II collagen in group D was significantly
lower and the superficial layer was defective (P<0.05).
Compared with group B, the expression of MMP-1, MMP-3 and
MMP-13 in articular cartilage decreased in group C, and
increased in group D compared with group B (P<0.05). H2S
can inhibit the expression of MMP-1, MMP-3 and MMP-13 in
articular cartilage, reduce the degradation of collagen II
in articular cartilage, and protect articular cartilage in
osteoarthritis.
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Article: Evaluation of right ventricular systolic function in patients with chronic renal insufficiency with 3D-STI
by Yingtao Li, Rong Zhang, Weigang Liu, Lan Ma, Rong Li, Yan Zhu, Dongmei Sun
Chronic Diseases Prevention Review 2019 3(10) 7-10; published online 18 April 2019
Abstract:
To evaluate the clinical value of 3D-STI in the evaluation
of right systolic function in patients with chronic renal
insufficiency. 34 patients with mild chronic renal
insufficiency (CKD1-2 group), 44 patients with moderate to
severe chronic renal insufficiency (CKD3-5 group), who
accepted treatment in the West Coast of Qingdao University
Affiliated Hospital from January 2016 to May 2018, and 41
healthy volunteers (control group) were enrolled. 3D-STI
analysis was underwent, and the indicators, including right
ventricle end-systolic volume (RVESV), right ventricle
end-diastolic volume (RVEDV), three-dimensional right
ventricular ejection fraction (3D-RVEF), right ventricular
longitudinal strain (RVGLS) and right ventricular free wall
longitudinal strain (RVFLS) were compared. Compared with the
normal group, the RVEDV and RVESV in the mild group
increased, while the 3D-RVEF, RVCLS, and RVFLS decreased
(P>0.05). Compared with the normal group and the mild group,
the RVESV and RVESV were significantly increased in the
moderate to severe group, while 3D-RVEF, RVCLS, and RVFLS
were significantly decreased with the statistically
significant difference (P<0.05). It could be concluded that
3D-STI can detect changes in right ventricular systolic
function in patients with renal insufficiency and provide
valuable information for clinical treatment.
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Article: Correlation between coronary slow flow phenomenon and Cystatin C
by Mengwan Li, Lu Han, Zhexun Lian, Kai Tan
Chronic Diseases Prevention Review 2019 3(10) 11-14; published online 18 April 2019
Abstract:
Our study was to investigate the factors relating to the
coronary slow flow phenomenon (CSFP) and to observe the
changes of Cystatin C (CysC) level in patients with coronary
slow flow phenomenon (CSFP) and clinical predictive value.
The CysC levels were examined. The data of patients with
coronary angiography were collected. The proportion of male
in the CFSP group was significantly higher than the other
two groups (p<0.05). The age and creatinine level were
significantly lower than the other two groups (p<0.05). The
level of cystatin C, uric acid and proportion of smoking
history in patients with CSFP was higher than that in normal
group and lower than that in mild stenosis group (p<0.05).
Cystatin C was an independent risk factor for CSFP (OR>1),
while uric acid and history of smoking are not related to
CSFP. In the CSFP group, LAD, LCX and appears RCA were
75.36%, 68.12% and 23.91%, respectively. There were no
significant differences in gender, age, cystatin C, UA,
CREA, UREA, and smoking history among the different vessels
in the CSFP group (P>0.05). Serum cystatin C level is
associated with the occurrence and development of CSFP, and
it can be the predictor of CSFP.
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Article: Research status of alcohol consumption and obesity
by Xiang Xu, Shaojie Wang
Chronic Diseases Prevention Review 2019 3(10) 15-20; published online 18 April 2019
Abstract:
Obesity has become a common disease. According to the data
reported in 2010, the prevalence of central obesity above 18
years old was 30%-40%. Obesity not only is a serious chronic
disease, but also increases the morbidity and mortality of
some diseases, such as cardiovascular disease, diabetes,
cancer and musculoskeletal disorders. In male, most studies
have demonstrated that alcohol consumption is associated
with obesity, and those studies have rendered a J-shaped
dose-response trend; in female, most studies have suggested
that it is no association or inverse association. The
conclusion of drinking different categories is slightly
different. Beer is a risk factor for central obesity; some
studies have suggested that it’s a J-shaped relationship
between wine consumption and body mass index (BMI); there is
a linear correlation between spirits and obesity. Some
studies have thought that alcohol consumption is a U-shaped
relationship between obesity, and heavy drinking is a risk
factor for obesity, and moderate drinking is recommended. At
present, there is no consistent conclusion on the
relationship between alcohol consumption and obesity.
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Article: The Effects of nutraceutical combinations based on red yeast rice supplementation on cholesterol Levels in adults
by Huimin Cheng, Hui Liang
Chronic Diseases Prevention Review 2019 3(10) 21-24; published online 20 April 2019
Abstract:
Red yeast rice (RYR) is the fermented functional food with
Monacus purpureus onto rice. It includes a multitude of
bioactive components monacolins, polyketide pigments, and
unsaturated fatty acids. The bioactive ingredient monacolin
K of red yeast rice is similar to the synthetic drug
lovastatin but has no serious side effects of statins. This
mini-review summarizes the effects of RYR on cholesterol
levels in patients with hyperlipidemia and statin
intolerance.
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Article: Risk factors related to hypertension in tuberculosis patients
by Boyang Wei, Qian Liu, Chunjiang Dong, Baoli Du, Tingyan Kou, Jiaqi Song, Qiuzhen Wang
Chronic Diseases Prevention Review 2019 3(10) 25-30; published online 29 April 2019
Abstract:
Tuberculosis and high blood pressure are two major diseases
that affect human health. According to the WHO survey,
tuberculosis is the ninth cause of death in the global.
Nearly a quarter of the world's population suffers from high
blood pressure, and hypertension has become an independent
factor in the death of certain diseases such as stroke and
ischemic heart disease. This article mainly discusses the
risk factors of hypertension in pulmonary tuberculosis
patients, and provides a scientific basis for the early
detection and prevention of hypertension in tuberculosis
patients. A total of 100 patients with tuberculosis were
enrolled in the study, 9 of them had hypertension. Patient
data were collected by querying medical records and
questionnaires. Logistic regression analysis was used to
analyze the risk factors of pulmonary tuberculosis patients
with hypertension. The distribution of Age and BMI in
patients with hypertension and normal blood pressure was
statistically significant. Univariate logistic regression
analysis showed that age 50 years (OR (95% CI),
8.640(1.079-76.251)) and BMI 24 (OR (95% CI),
4.766(1.146-19.822)) were the risk factors for pulmonary
tuberculosis with hypertension (P<0.05), while
Multivariate logistic regression analysis showed that only
BMI ³ 24 (OR (95% CI), 4.766(1.146-19.822)) was the risk
factor for pulmonary tuberculosis with hypertension
(P<0.05). We found that the prevalence of hypertension in
tuberculosis patients is higher, and the risk factors for
hypertension are overweight/obese. Elderly age may also be
the risk factor of hypertension in tuberculosis patients,
which need a further study expanding the sample.
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Article: A comparative analysis of simultaneous and staging total knee arthroplasty in one hospitalization cycle
by Tao Ding, Shaoqi Tian, Jiangjun Liu, Xianan Li, Guoqing Chu, Kang Sun
Chronic Diseases Prevention Review 2019 3(10) 31-35; published online 29 April 2019
Abstract:
To evaluate the efficacy and safety of bilateral TKA in
patients with knee osteoarthritis (KOA) during one
hospitalization cycle. Bilateral knee osteoarthritis in 56
patients studied retrospectively. 30 patients underwent
bilateral TKA operation as control group, 26 patients
underwent bilateral TKA operation as observation group by
stages. The preoperative general condition, intraoperative
condition, postoperative recovery and incidence of
complications were compared and analyzed among the two
groups. No significant differences have been observed in
age, sex composition, BMI and NNIS scores in the two groups
before operation (P>0.05); No significant differences have
been observed in joint activity, HSS score, VAS score and
complications in the two groups after operation (P>0.05);
The observation group showed a shorter operative time and
postoperative hospital stay, and the medical cost was lower
in the observation group when compared with the control
group (P<0.05). The blood loss and transfusion, however,
were significantly higher in the observation group when
compared with the control group (P<0.05). For first-time
patients underwent bilateral total knee arthroplasty, there
was no statistically significant in safety and effectiveness
between the observation group and control group under strict
perioperative management and careful evaluation. However,
the observation group has the advantages of short total
operation time and postoperative hospital stay, economical
applicability and quick postoperative recovery, and thus
deserving popularization.
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Article: Study on the effect of smoking on the risk of active pulmonary tuberculosis in patients with type 2 diabetes mellitus
by Chunjiang Dong, Tingyan Kou, Yufeng Liu, Yue Zou, Limei Sun, Hong Tian,
Boyang Wei, Qian Liu, Yuze Mu, Xuezhao Lu, Qiuzhen Wang
Chronic Diseases Prevention Review 2019 3(10) 36-41; published online 29 April 2019
Abstract:
To investigate the effect of smoking on the risk of active
pulmonary tuberculosis (PTB) in patients with type 2
diabetes mellitus (DM). Using a case control study design
matched with 1:2, the newly diagnosed patients with active
pulmonary tuberculosis and type 2 diabetes mellitus (DM-PTB)
in a municipal hospital from January 2017 to January 2018
were selected as the case group. At the same time, the
patients with simple DM were treated in a municipal general
hospital as the control group. The patients in two hospitals
who met the inclusion criteria were surveyed by specially
trained investigators using a unified questionnaire, and the
patients were measured by physiometric measurements and
related laboratory tests. A total of 315 subjects were
included in this study, including 105 cases with DM-PTB in
the case group and 210 cases with DM in the control group.
According to the distribution of smoking, the proportion of
smokers in the case group was significantly higher than that
in the control group (P<0.001). Multivariate conditional
Logistic regression analysis showed that poor glycemic
control, tuberculosis (TB) exposure history and smoking were
risk factors for active PTB in DM patients. Compared with
nonsmokers, current smokers (OR, 95% CI: 12.194, 3.527,
42.162) and former smokers (OR, 95% CI: 4.591, 1.073,
19.638) had significantly higher risk of active PTB, and the
increased risk of current smokers was more obvious. Smoking
is an independent risk factor for active pulmonary
tuberculosis in patients with type 2 diabetes mellitus.
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