Chronic Diseases Prevention Review (Online ISSN: 2158-0820)

by  Di Meng, Xiaocao Tian, Hua Zhang, Xiaohui Sun, Shaojie Wang, Yu Guo, 

       Zheng Bian, Zengchang Pang, Ruqin Gao

Chronic Diseases Prevention Review 2020 4(14) 1-6; published online  3 April 2020

Abstract:   To understand the morbidity of fruit intake in Licang District of Qingdao and analyze the relationship between the frequency of fruit intake and the incidence of hypertension in the baseline population. The baseline survey data of the China Kadoorie Biobank (CKB) Qingdao project site from 2004 to 2008 were collected and analyzed. A total of 35509 subjects were enrolled, the ratio of male to female was 1:1.27. The morbidity of hypertension in the study population was 36.11% for men and 30.90% for women (c2=113.38, P<0.05). Compared with those who rarely eat fruit, the subjects with higher frequency of fruit intake are younger, mostly female, with higher education level and higher family income. With the increase of age, the proportion of people who eat fruit every day is becoming smaller and smaller. In the total population, compared with first group, the other four groups were all protective factors of hypertension (P<0.05), and the risk of hypertension was lower in fifth group (OR=0.49, 95% CI:0.42-0.55). In male samples, except the second group, the other groups could reduce the risk of hypertention (P<0.05); in female samples, only five groups could reduce the risk of hypertension (OR=0.61, 95% CI:0.46-0.80). Increasing the frequency of fruit intake is beneficial to reduce the incidence of hypertension in adults in Qingdao, and increasing the level of fruit intake has a more important protective effect on male samples.

by  Xuemei Lu, Xiaopeng Ji, Lei Han

Chronic Diseases Prevention Review 2020 4(14)7-11; published online  3 April 2020

Abstract: In this study, we planned to explore the effect of nutritional therapy on the improvement of gestational diabetes mellitus (GDM) with anemia and its impact on pregnancy outcomes, and to provide a reference for the reasonable diet of patients with GDM and anemia. 137 subjects with gestational diabetes and anemia were collected among the pregnant women undergoing obstetric examination and delivery in the obstetrics department of Qingdao University Affiliated Hospital. These subjects were randomly divided into the intervention group (n = 75) and the control group (n = 62). The intervention group was given individualized nutritional treatment according to the weight growth, dietary intake, blood glucose and hemoglobin (Hb), while the control group was only given routine obstetric examinations and general health education. There were no significant differences between the intervention group and the control group in age, gestational week, and pre - pregnancy BMI before nutritional treatment (P > 0.05). After nutritional treatment, the fasting blood glucose (FBG), 1 - hour postprandial blood glucose (1hPG) and 2 - hour postprandial blood glucose (2hPG) decreased and hemoglobin increased in the intervention group (P < 0.05). The weight gained during pregnancy was lower than the intervention group (P < 0.05) compared with the control group, and the incidence of premature rupture of membranes (PROM), cesarean sectionand giant fetus ( ≥ 4000 g ) were lower (P < 0.05). For patients with GDM and anemia, nutritional therapy was conducive to controlling blood glucose, increasing hemoglobin, allowing reasonable weight gain during pregnancy, and reducing the incidence of caesarean section, PROM and giant fetus.

by  Jie Wang, Tang Li

Chronic Diseases Prevention Review 2020 4(13) 12-16; published online  3 April 2020

Abstract:  To investigate glycemic control in children with type 1 diabetes mellitus (T1DM) who used of continuous subcutaneous insulin infusion (CSII) in Qingdao area, to explore the CSII in long-term curative effect in treatment of children with T1DM, to analyze the related factors that influence the effect of CSII on T1DM, and to provide guidance for the follow-up management of CSII in long-term therapy. A self-made questionnaire was used to investigate 60 T1DM children who were followed up in the Department of Endocrinology of Qingdao Women and Children Hospital. The purpose was to understand the general situation of children and treatment-related information. The most recent mean Glycosylated Hemoglobin A1c (HbA1c) was (7.12±1.11)% in children with T1DM who were treated with CSII, and the overall control level was good, which was significantly lower than the last mean HbA1c (9.58±2.08)% before CSII treatment. There was a significant difference in the HbA1c level before and after CSII treatment (P<0.05). There were significant differences in the HbA1c level before and after CSII treatment in diet control, daily exercise time, frequency of visit and self-monitoring frequency of blood glucose (P < 0.05). After treatment with CSII, the glycemic control level of T1DM children in Qingdao area was well controlled, and the blood glucose was improved obviously, among which good diet control, regular exercise, regular follow-up visits and especially high-frequency blood glucose monitoring are all conductive to blood glucose control.

by  Xuezhao Lu, Yao Wang, Chen Qu, Yuze Mu, Chunyan Li, Huihui Li, Bingkun Liu, Wenbo Cui,

        Wenwen Zhang, Qiuzhen Wang

Chronic Diseases Prevention Review 2020 4(14)17-24; published online  5 April 2020

Abstract:   Helicobacter pylori (H. pylori), a gram-negative, spiral-shaped pathogenic bacterium, causes many gastrointestinal and extra-gastric diseases. The prevalence of Helicobacter pylori varies in different countries of the world. The purpose of this study was to investigate the prevalence and risk factors of H. pylori infection in Qingdao. A population based cross-sectional study was carried out at the physical examination center of the Affiliated Hospital of Qingdao University from April to August 2018. 1690 cases were given H. pylori urease-IgG antibodies detection in serum for the diagnosis of H. pylori infection. The rate of H. pylori infection was 27.6%. The univariate logistic regression analysis indicated that the neutrophil count, the rate of age≥45, male, overweight/obesity, smoking, alcohol using, high total cholesterol (TC), high white blood cell (WBC), hypertension, diabetes and nonalcoholic fatty liver disease (NAFLD) in H. pylori-positive subjects were significantly higher than the indicators of H. pylori-negative subjects (P<0.05). The multivariate logistic regression analysis indicated that age≥45 (OR=1.30, 95%CI: 1.01-1.66), overweight/obesity (OR=1.36, 95%CI: 1.05-1.75), high WBC (OR=2.09, 95%CI: 1.16-3.77), diabetes (OR=1.78, 95%CI: 1.14-2.76) and NAFLD (OR=1.63, 95%CI: 1.21-2.19) were associated with the increased rate of H. pylori infection. Armed with these data, medical doctors will be able to better identify high-risk groups of H. pylori and provide patients with education about management and prevention/eradication strategies.

by Ming Zhang, Chenglong Zhang, Guangqun Xing

Chronic Diseases Prevention Review 2020 4(14)25-29; published online  5 May 2020

Abstract:  Currently, ANCA-associated vasculitides (AAV) has been testified to be associated with infectious diseases, in which Neutmphil Extracellular Traps (NETs) played a crucial role as a bridge. In this paper, the specific mechanism of NETs in infectious diseases and the pathogenesis of AAV is analyzed based on the characteristics of NETs.