Chronic Diseases Prevention Review (Online ISSN: 2158-0820)

by  Hongjun Zhao, Xiaolan Ren, Pengfei Ge

Chronic Diseases Prevention Review 2017 1(4) 1-2; published online 25 July 2017

Abstract: The development and spread of nanotechnologies in manufacturing work worldwide calls for close attention to the potential health risks for workers who might be exposed to nanometer-scale materials. Since no systematic epidemiologic studies of workers exposed to nanomaterials have yet been conducted, it is urgent to understand health effects of nanomaterials to workers to begin this occupational epidemiology study.

by  Ziyi Xiao, Lei Han, Ruonan Wu

Chronic Diseases Prevention Review 2017 1(4) 3-8; published online 25 August 2017

Abstract: Excessive intake of fructose is linked to the development of type 2 diabetes and obesity. However, the effect of fructose consumption on fetal development during pregnancy is not well established. The aim of this study was examined the impact of the fructose intake during pregnancy on the placental and fetus development. Dams fed fructose throughout gestation leads to fetal weights was decreased as the dose of fructose intake increasing；Meanwhile, the number of absorbing birth and stillbirth was increased. This change was not observed in control group (CG) and normal fructose group (NFG). Fructose feeding had no effect on the rate of skeletal deformities and visceral hemorrhage. The placental weight was decreased in super high fructose group (SHFG); Serum fructose level was significantly increased in high fructose group (HFG) and SHFG. The placental lever of vascular endothelial growth factor (VEGF) was lower, whereas soluble fms‑like tyrosine kinase‑1 (sFlt‑1) concentration is higher in HFG and SHFG. In conclusion, maternal high fructose intake during pregnancy increased the risk of stillbirth, absorbed fetus, and induced the toxicity of fetal development and results in vascularization of the placenta.

by  Xi Meng, Fucheng Song, Hongzong Si

Chronic Diseases Prevention Review 2017 1(4) 9-12; published online 25 August 2017

Abstract: The prevalence and mortality of cervical cancer ranked first in the malignancies of the female reproductive system, and the incidence is increasing in recent years, especially in developing countries. Clinical treatment of cervical cancer mainly takes the combination of surgery, radiotherapy and chemotherapy method. At present, cisplatin is still the preferred drug for chemotherapy, but its drug resistance has seriously hampered its treatment of cervical cancer.To improve the therapeutic effect of cisplatin on cervical cancer patients, and improve the sensitivity of cervical cancer cells to cisplatin, we investigated the cisplatin resistance mechanism of cervical cancer cells and reviewed them, to provide a scientific basis for better clinical effect of cisplatin.

by  Kaihua Liu, Shenqian Li

Chronic Diseases Prevention Review 2017 1(4) 13-15; published online 25 September 2017

Abstract: The primary urachal carcinoma is a very rare malignant tumor. It generally presents as a high grade, high stage tumor and in most of the cases it has regional or distant metastasis at the time of presentation. It is known to have a uniformly poor prognosis. In this paper, we present here a very interesting and rare case report of primary urachal adenocarcinoma with signet ring cell carcinoma in a 58-year-old male who presentedthe lower abdomen has a mass and felt discomfort. In this case, urachal carcinoma were successful treated by surgery using partial bladder cystectomy with excision of the urachal mass and umbilicus,and the patient also underwentsystematicchemotherapy.Followed up for 10 months, the patient has not experienced recurrence or other metastasis.Organpreserving partial cystectomy provides higher quality of the life and chemotherapyis the primary methodused to treat the disease.